Publicación

Tipo de publicación: Artículos científicos (Publicados en revistas de divulgación o científicas)

Título del artículo: In Vitro Assessment of Antiproliferative Activity and Cytotoxicity Modulation of Capsicum chinense By-Product Extracts

Registrado por: Mabel Fragoso-Serrano y Lilian Dolores Chel Guerrero

Año de publicación: 2022

Resumen: Capsicum chinense J., also known locally as habanero pepper, is a medicinal herb known for its pharmacological properties. Its properties are attributed to the capsaicinoids and polyphenols found in its fruit and polyphenols in its by-products. The anticancer potential of C. chinense by-products remains unexplored. This study aimed to evaluate the antiproliferative activity and modulation of the cytotoxicity of extracts obtained from C. chinense by-products of plants grown on black and red soils of Yucatan, Mexico. Dry by-product extracts were obtained using maceration, a Soxhlet, and supercritical fluid extraction. In vitro antiproliferative activity and cytotoxicity modulation were evaluated by the sulforhodamine B method. The extract of leaves of plants grown on black soil obtained by maceration displayed selective high cytotoxicity against colorectal cancer cells, IC50 HCT–15 = 16.23 +/- 2.89 ug/mL. The leaf and stem extracts of plants grown on red soil obtained
by maceration potentiated the vinblastine’s effect against parental breast cancer cells, MCF–7/Sens, with a reversion factor of 362.50-fold. Additionally, the extract of stems from plants grown on black
soil obtained by supercritical fluid extraction and all the by-product extracts from plants grown on black soil obtained through maceration increased the effect of vinblastine against MCF–7/Vin+ with a reversion factor from 5.06- to 7.78-fold. These results highlight the anticancer potential of C. chinense by-products.

Editorial:

Número de páginas:

Autor(es): Lilian Dolores Chel-Guerrero, Matteo Scampicchio, Giovanna Ferrentino, Ingrid Mayanín Rodríguez-Buenfil, and Mabel Fragoso-Serrano

Campo: Biología y Química

Disciplina: Salud

Subdisciplina:

Número de registro: Doi: 10.3390/ app12125818